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KMID : 1103720170760030221
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Journal of the Korean Society of Radiology
2017 Volume.76 No. 3 p.221 ~ p.228
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Rapid Progression of Gliomatosis Cerebri to Secondary Glioblastoma, Factors That Affect the Progression Rate: A Case Report
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Kim Hee-Kyung
Yu In-Kyu
Kim Seung-Min
Kim Joo-Heon
Lee Seung-Hoon
Lee Seung-Yeon
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Abstract
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Glioblastomas may develop de novo or through progression from low-grade or anaplastic astrocytomas. The term ‘primary glioblastoma’ refers to a glioblastoma that lacks a precursor lesion and has a clinical history of less than three months. On the other hand, the term ‘secondary glioblastoma’ indicates that the glioblastoma has progressed from a low-grade tumor after a long latency period and often manifests in younger patients. These subtypes of glioblastoma develop via different genetic pathways, and they differ in prognosis and response to therapy. Thus, differential diagnosis of these subtypes and prediction of the factors that affect the progression from low-grade diffuse astrocytoma to secondary glioblastoma would be clinically very important. We present a rare case of secondary glioblastoma, which developed only three months after the follow up imaging evaluations, with a history of low grade glioma, and present the factors that cause rapid progression.
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KEYWORD
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Glioblastoma, Secondary, IDH1 Protein, Human, Disease Progression
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